lead-poisoned water in schools scandal
95% goes to RBC and bones. Binds and inhibits anything with sulfhydryl groups, and it is toxic to mitochondria. Key enzymes in heme synthesis are ALA-dehydratase and ferrochelatase. Thus you accumulate a lot of PROTOPORPHYRIN (FEP). This binds to zinc, and forms ZPP. Both of these are also raised in iron deficiency. Shorterned RBC survival and basophilic stippling (RNA can't be broken down). Iron deficiency enhances lead toxiticy, get even higher FEP and your intestine absorbs both iron and l...