Greenville, South Carolina Nestled in South Carolina's northwestern corner, Greenville sits in the top third of the Milken Institute's rankings. Unemployment rate is 7.1%, 0.8% below the national average. Cost of living beats the U.S. average by 6%, and the median home price of $156,000 is $30,000 under the national average. South Carolina has an excellent tax climate for senior citizens. The doctors per capita ratio is high.