7 Crucial Things to do in Santorini when having 48 hours -The best taste of the island. The best start of exploring Santorini Island is by doing Fira to Oía Walk. Then another with taking Extensive pictures of Oía. For dinner Aegeon dinning with a view of Imerovigli. The next day Rent an ATW and be careful driving – Red Beach, Kamari Beach, Mesa Gonia, Exa Gonia, Santo Vinery and Sunset view. Of course Santo Winery with Sunset View.